In the 13 years since Qubes OS was released, the broader desktop ecosystem has changed in many ways. Some are good for Qubes OS, such as broader hardware virtualization support and the rise of immutable OS. Others are problematic for Qubes OS, such as increasing dependence on GPU acceleration. Yet others are neutral but not backwards compatible, such as the switch from X11 to Wayland and from PulseAudio to PipeWire. In this talk, I will discuss how Qubes OS can adapt to the changing ecosystem and the new use-cases this will open up.